13q Deletion MM (CLL), Heparin Bone Marrow in Mumbai

Overview

The 13q Deletion (CLL), Heparin Bone Marrow test is an advanced genetic test performed on a heparinized bone marrow sample to detect the deletion of chromosome 13q14, one of the most common cytogenetic abnormalities associated with Chronic Lymphocytic Leukemia (CLL). The test is performed using Fluorescence In Situ Hybridization (FISH), a highly sensitive technique that identifies chromosomal abnormalities in bone marrow cells. Detection of a 13q deletion provides valuable prognostic information. When this deletion occurs as the only chromosomal abnormality, it is generally associated with a more favorable prognosis than other CLL-related genetic abnormalities. Bone marrow testing is particularly useful when peripheral blood findings are inconclusive or when a detailed evaluation of bone marrow involvement is required. This test is commonly ordered alongside other CLL cytogenetic markers such as 11q (ATM) Deletion, 17p (TP53) Deletion, Trisomy 12, and IGHV Mutation Analysis to provide a comprehensive genetic assessment for diagnosis, prognosis, and treatment planning.

Why Take This Test?

• To detect 13q14 deletion in patients with suspected or confirmed CLL. To assist in the diagnosis and classification of Chronic Lymphocytic Leukemia. To evaluate disease prognosis and genetic risk. To guide personalized treatment decisions. To complement other cytogenetic and molecular investigations. To monitor disease progression and treatment response.