11q Deletion ATM (CLL), Heparin Bone Marrow in Mumbai

Overview

The 11q Deletion ATM (CLL), Heparin Bone Marrow test is a specialized genetic test performed on a heparinized bone marrow sample to detect the deletion of the ATM (Ataxia-Telangiectasia Mutated) gene located on chromosome 11q22–q23. This chromosomal abnormality is an important prognostic marker in Chronic Lymphocytic Leukemia (CLL) and is associated with a higher-risk disease course, extensive lymph node involvement, and faster disease progression. The test is typically performed using Fluorescence In Situ Hybridization (FISH), a highly sensitive technique that identifies specific chromosomal abnormalities in bone marrow cells. Bone marrow testing may be recommended when peripheral blood findings are inconclusive or when a detailed assessment of bone marrow involvement is required. This test is often performed alongside other CLL cytogenetic markers such as 13q Deletion, 17p (TP53) Deletion, Trisomy 12, and IGHV Mutation Analysis to provide a comprehensive genetic profile for diagnosis, prognosis, and personalized treatment planning.

Why Take This Test?

• To detect 11q (ATM) gene deletion in bone marrow cells. To support the diagnosis of Chronic Lymphocytic Leukemia (CLL). To evaluate disease prognosis and genetic risk. To guide personalized treatment decisions. To complement cytogenetic and molecular testing. To monitor disease progression and treatment response.

What It Measures

How to Prepare

• 1No fasting is required. A heparinized bone marrow sample should be collected by a qualified healthcare professional using sterile techniques. Inform your healthcare provider about previous chemotherapy
• 2bone marrow transplantation
• 3or ongoing cancer treatment. Follow your physician's instructions regarding bone marrow aspiration and sample collection.

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