11q Deletion ATM (CLL), Heparin Blood in Lucknow

Overview

The 11q Deletion ATM (CLL), Heparin Blood test is a specialized genetic test used to detect the deletion of the ATM (Ataxia-Telangiectasia Mutated) gene located on chromosome 11q22–q23. This chromosomal abnormality is commonly associated with Chronic Lymphocytic Leukemia (CLL) and is an important prognostic marker. Patients with an 11q deletion may have a more aggressive disease course, extensive lymph node involvement, and may require closer monitoring or specific treatment approaches. The test is typically performed using Fluorescence In Situ Hybridization (FISH) on a heparinized blood sample, allowing rapid and accurate detection of chromosomal abnormalities without requiring dividing cells. This test is often ordered along with other CLL prognostic markers such as 13q deletion, 17p (TP53) deletion, Trisomy 12, and IGHV mutation analysis to provide a comprehensive genetic profile for personalized treatment planning.

Why Take This Test?

• To detect 11q (ATM) gene deletion in patients with suspected or confirmed CLL. To assist in the diagnosis and classification of Chronic Lymphocytic Leukemia. To evaluate disease prognosis and risk category. To guide personalized treatment decisions. To monitor disease progression in selected patients. To support comprehensive genetic evaluation in hematological malignancies.

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