ANA (Anti Nuclear Antibody) Screening by EIA: What It Detects, Normal Range
Sample Type
Serum
Parameters
1
Report Time
Same day
Fasting
No fasting required.
Overview
The ANA (Anti-Nuclear Antibody) Screening by EIA, Serum test detects Anti-Nuclear Antibodies (ANA) using the Enzyme Immunoassay (EIA) method. ANA are autoantibodies directed against components of the cell nucleus and are commonly found in individuals with autoimmune diseases. This screening test is widely used as the initial laboratory investigation for patients with symptoms suggestive of autoimmune disorders, including joint pain, persistent fatigue, skin rashes, unexplained fever, muscle weakness, dry eyes, and dry mouth. A positive ANA result may be associated with conditions such as Systemic Lupus Erythematosus (SLE), Sjögren's syndrome, Systemic Sclerosis (Scleroderma), Mixed Connective Tissue Disease (MCTD), Polymyositis, and Dermatomyositis. However, ANA positivity may also occur in healthy individuals, especially with advancing age, and therefore should always be interpreted alongside clinical findings and additional laboratory tests. If the screening result is positive, further testing such as ANA by Indirect Immunofluorescence (IFA), ENA Profile, Anti-dsDNA, or disease-specific autoantibodies may be recommended.
What It Measures
Why Take This Test?
- To screen for Systemic Lupus Erythematosus (SLE) and other autoimmune diseases. To investigate unexplained joint pain
- fatigue
- rashes
- or muscle weakness. To evaluate suspected connective tissue disorders. To support diagnosis of autoimmune rheumatic diseases. To guide further autoimmune antibody testing. To assist in clinical diagnosis and patient management.
How to Prepare
- 1No fasting or special preparation is required. Inform your healthcare provider about current medications
- 2recent infections
- 3or any diagnosed autoimmune conditions. A blood sample will be collected by a trained healthcare professional.
Description
Screens for Anti-Nuclear Antibodies (ANA) in serum to help identify autoimmune disorders such as Systemic Lupus Erythematosus (SLE) and related connective tissue diseases.